Lornithine is an amino acid that is primarily used in the urea cycle, which eliminates excess nitrogen from the body. It isn’t an essential amino acid in humans, meaning that it can be synthesized in the body.


  • Supports urea cycle in the liver
  • Looks after skin repair process
  • Helps in relieving stress
  • Role in wound healing
  • Manages fatigue
  • Helps recover from alcohol hangover
  • Supports physical form
  • Anxiety reliving effect
  • Improves patients with hepatic encephalopathy
  • Important precursors for body functions

Top L-Ornithine 

Top  10 Health benefits of L-ornithine

L-ornithine is a non-essential amino acid that is present in the body and is widely known for its detoxification effect. Ornithine, like other nutrients and substances, supports a lot of bodily function and helps in relieving many stressful conditions. The multiple ways in which it ensures good health are as follows:

1. Supports urea cycle in the liver

Ornithine, citrulline, and arginine are the three amino acids that play their essential roles in the urea cycle. These nutrients help in speeding up the ammonia removal pathway. There are some rare genetic diseases that disturb the urea cycle. The L-ornithine supplements facilitate the process in such patients.

2. Looks after skin repair process

The damaged skin heals slowly but ornithine supplement helps in quick skin repair and healing. A study supports the use of L-ornithine in a burn-injured patient. The supplement offered better clinical recovery.

3. Helps in relieving stress

Many studies are conducted on revealing the effect of L-ornithine on reducing the stress and improving sleeping patterns. The results for stress reduction were positive. It also showed that the nutrient reduces body cortisol hormone levels and improves insomnia as well.

4. Role in wound healing

An experiment was conducted on laboratory animals and they were given ornithine supplements. The results showed that it enhanced wound healing along collagen production. This study was published in “Journal of Surgical Research” in August 2002.

5. Manages fatigue

The non-essential amino acid ornithine is converted by the kidneys into arginine. Arginine is known for its healthy effect on nitric oxide-dependent dilation of the blood vessels and improved blood flow. All of this helps in reducing body fatigue, especially the one experienced after exercise.

6. Helps recover from alcohol hangover

The toxic substance ammonia is detoxified in the liver. The ornithine nutrient supports this role which is why it is thought that excessive intake of alcohol and its hangover effect can be reversed by ornithine supplementation.

7. Supports physical form

Arginine, the by-product of ornithine, once again rules the discussion when it comes to the effect of the amino acids on enhancing endurance and physical fitness. The ‘Journal of Sports Medicine and Physical Fitness’, talks about a study in which the participants were given ornithine and arginine supplements. This showed that the participants experienced increased strength and lean body mass in accelerated time frame while performing strength training programs.

8. Anxiety reliving effect

As this supplement can move through the blood-brain barrier, it is known that it helps in alleviating anxiety in the user.

9. Improves patients with hepatic encephalopathy

Hepatic encephalopathy is a reversible neurocognitive impairment caused by the accumulation of the nitrogenous substances. Ammonia builds up in the body and crosses the brain to inhibit its functioning. Adding ornithine to diet supports the detoxification process in the liver and reverses this condition.

10. Important precursors for body functions

Ornithine is a known precursor for glutamic acid and proline. Glutamic acid is known for its neurotransmitting effect while proline facilitates the breakdown of protein for cellular use.

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Content Contributor: Mark

Mark has been a fitness enthusiast for most of his adult life. After a lifelong struggle of food addiction, Mark's mission is to share his success stories with the world.